Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
Identifieur interne : 001906 ( Main/Exploration ); précédent : 001905; suivant : 001907Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
Auteurs : Pan Wang [République populaire de Chine] ; Limin Han [République populaire de Chine] ; Hong Shen [République populaire de Chine] ; Pengfeng Wang [République populaire de Chine] ; Cuicui Lv [République populaire de Chine] ; Ganye Zhao [République populaire de Chine] ; Jing Niu [République populaire de Chine] ; Lixiang Xue [République populaire de Chine] ; Qiming Jane Wang ; Tanjun Tong [République populaire de Chine] ; Jun Chen [République populaire de Chine]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Descripteurs français
- KwdFr :
- Amorces ADN (génétique), Animaux, Espèces réactives de l'oxygène (métabolisme), Humains, Immunoprécipitation de la chromatine, Immunotransfert, Petit ARN interférent (génétique), Protein kinase C-delta (métabolisme), Protéine kinase C (métabolisme), Protéines G ras (métabolisme), Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée NOD, Test ELISA, Transduction du signal (physiologie), Vieillissement de la cellule (physiologie).
- MESH :
- génétique : Amorces ADN, Petit ARN interférent.
- métabolisme : Espèces réactives de l'oxygène, Protein kinase C-delta, Protéine kinase C, Protéines G ras.
- physiologie : Transduction du signal, Vieillissement de la cellule.
- Animaux, Humains, Immunoprécipitation de la chromatine, Immunotransfert, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée NOD, Test ELISA.
English descriptors
- KwdEn :
- Animals, Cell Aging (physiology), Chromatin Immunoprecipitation, DNA Primers (genetics), Enzyme-Linked Immunosorbent Assay, Humans, Immunoblotting, Mice, Mice, Inbred NOD, Protein Kinase C (metabolism), Protein Kinase C-delta (metabolism), RNA, Small Interfering (genetics), Reactive Oxygen Species (metabolism), Real-Time Polymerase Chain Reaction, Signal Transduction (physiology), ras Proteins (metabolism).
- MESH :
- chemical , genetics : DNA Primers, RNA, Small Interfering.
- chemical , metabolism : Protein Kinase C, Protein Kinase C-delta, Reactive Oxygen Species, ras Proteins.
- physiology : Cell Aging, Signal Transduction.
- Animals, Chromatin Immunoprecipitation, Enzyme-Linked Immunosorbent Assay, Humans, Immunoblotting, Mice, Mice, Inbred NOD, Real-Time Polymerase Chain Reaction.
Abstract
Oncogene-induced senescence (OIS) is an initial barrier for cancer development. Reactive oxygen species (ROS) play critical roles in oncogenic Ras OIS. Senescent cells develop a senescence-associated secretory phenotype (SASP), which has important role in tumor suppression and tissue repair. However, the mechanisms underlying the SASP regulation are not clear. In this paper, we show that ROS-protein kinase Cδ (PKCδ)-protein kinase D1 (PKD1) axis is essential for SASP induction and maintenance via modulation of NF-κB activity. Considering the pivotal role of both SASP and ROS in systemic aging and age-related diseases, the link between ROS-PKCδ-PKD1 pathway and SASP regulation elucidated here may provide a new target to intervene in age-related inflammation and diseases.
Url:
DOI: 10.1073/pnas.1310972111
PubMed: 24828530
PubMed Central: 4040603
Affiliations:
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Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Ganye" sort="Zhao, Ganye" uniqKey="Zhao G" first="Ganye" last="Zhao">Ganye Zhao</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niu, Jing" sort="Niu, Jing" uniqKey="Niu J" first="Jing" last="Niu">Jing Niu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Department of Biochemistry and Molecular Biology,<institution>Capital Medical University</institution>, Beijing 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Biology,<institution>University of Pittsburgh School of Medicine</institution>, E1354 BST, Pittsburgh,<addr-line>PA</addr-line> 15261</nlm:aff></affiliation></author><author><name sortKey="Tong, Tanjun" sort="Tong, Tanjun" uniqKey="Tong T" first="Tanjun" last="Tong">Tanjun Tong</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff 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xml:lang="en" level="a" type="main">Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation</title><author><name sortKey="Wang, Pan" sort="Wang, Pan" uniqKey="Wang P" first="Pan" last="Wang">Pan Wang</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Limin" sort="Han, Limin" uniqKey="Han L" first="Limin" last="Han">Limin Han</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff 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last="Wang">Pengfeng Wang</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lv, Cuicui" sort="Lv, Cuicui" uniqKey="Lv C" first="Cuicui" last="Lv">Cuicui Lv</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Ganye" sort="Zhao, Ganye" uniqKey="Zhao G" first="Ganye" last="Zhao">Ganye Zhao</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niu, Jing" sort="Niu, Jing" uniqKey="Niu J" first="Jing" last="Niu">Jing Niu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Department of Biochemistry and Molecular Biology,<institution>Capital Medical University</institution>, Beijing 100069,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xue, Lixiang" sort="Xue, Lixiang" uniqKey="Xue L" first="Lixiang" last="Xue">Lixiang Xue</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qiming Jane" sort="Wang, Qiming Jane" uniqKey="Wang Q" first="Qiming Jane" last="Wang">Qiming Jane Wang</name><affiliation><nlm:aff id="aff4">Department of Pharmacology and Chemical Biology,<institution>University of Pittsburgh School of Medicine</institution>, E1354 BST, Pittsburgh,<addr-line>PA</addr-line> 15261</nlm:aff></affiliation></author><author><name sortKey="Tong, Tanjun" sort="Tong, Tanjun" uniqKey="Tong T" first="Tanjun" last="Tong">Tanjun Tong</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation><nlm:aff id="aff1">Peking University Research Center on Aging,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology,<institution>Peking University Health Science Center</institution>, Beijing 100191,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Aging (physiology)</term><term>Chromatin Immunoprecipitation</term><term>DNA Primers (genetics)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunoblotting</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Protein Kinase C (metabolism)</term><term>Protein Kinase C-delta (metabolism)</term><term>RNA, Small Interfering (genetics)</term><term>Reactive Oxygen Species (metabolism)</term><term>Real-Time Polymerase Chain Reaction</term><term>Signal Transduction (physiology)</term><term>ras Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN (génétique)</term><term>Animaux</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Humains</term><term>Immunoprécipitation de la chromatine</term><term>Immunotransfert</term><term>Petit ARN interférent (génétique)</term><term>Protein kinase C-delta (métabolisme)</term><term>Protéine kinase C (métabolisme)</term><term>Protéines G ras (métabolisme)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Souris</term><term>Souris de lignée NOD</term><term>Test ELISA</term><term>Transduction du signal (physiologie)</term><term>Vieillissement de la cellule (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Primers</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein Kinase C</term><term>Protein Kinase C-delta</term><term>Reactive Oxygen Species</term><term>ras Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Amorces ADN</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>Protein kinase C-delta</term><term>Protéine kinase C</term><term>Protéines G ras</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term><term>Vieillissement de la cellule</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Aging</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromatin Immunoprecipitation</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunoblotting</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunoprécipitation de la chromatine</term><term>Immunotransfert</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Souris</term><term>Souris de lignée NOD</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Oncogene-induced senescence (OIS) is an initial barrier for cancer development. Reactive oxygen species (ROS) play critical roles in oncogenic Ras OIS. Senescent cells develop a senescence-associated secretory phenotype (SASP), which has important role in tumor suppression and tissue repair. However, the mechanisms underlying the SASP regulation are not clear. In this paper, we show that ROS-protein kinase Cδ (PKCδ)-protein kinase D1 (PKD1) axis is essential for SASP induction and maintenance via modulation of NF-κB activity. Considering the pivotal role of both SASP and ROS in systemic aging and age-related diseases, the link between ROS-PKCδ-PKD1 pathway and SASP regulation elucidated here may provide a new target to intervene in age-related inflammation and diseases.</p></div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Wang, Qiming Jane" sort="Wang, Qiming Jane" uniqKey="Wang Q" first="Qiming Jane" last="Wang">Qiming Jane Wang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Pan" sort="Wang, Pan" uniqKey="Wang P" first="Pan" last="Wang">Pan Wang</name></noRegion><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><name sortKey="Han, Limin" sort="Han, Limin" uniqKey="Han L" first="Limin" last="Han">Limin Han</name><name sortKey="Lv, Cuicui" sort="Lv, Cuicui" uniqKey="Lv C" first="Cuicui" last="Lv">Cuicui Lv</name><name sortKey="Niu, Jing" sort="Niu, Jing" uniqKey="Niu J" first="Jing" last="Niu">Jing Niu</name><name sortKey="Shen, Hong" sort="Shen, Hong" uniqKey="Shen H" first="Hong" last="Shen">Hong Shen</name><name sortKey="Tong, Tanjun" sort="Tong, Tanjun" uniqKey="Tong T" first="Tanjun" last="Tong">Tanjun Tong</name><name sortKey="Wang, Pengfeng" sort="Wang, Pengfeng" uniqKey="Wang P" first="Pengfeng" last="Wang">Pengfeng Wang</name><name sortKey="Xue, Lixiang" sort="Xue, Lixiang" uniqKey="Xue L" first="Lixiang" last="Xue">Lixiang Xue</name><name sortKey="Zhao, Ganye" sort="Zhao, Ganye" uniqKey="Zhao G" first="Ganye" last="Zhao">Ganye Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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